In a city which prides itself on friendliness and yet has inequalities in health which persist despite our best attempts to tackle them, questions about our relationships to others are of key significance.This issue of otherness is ancient and contemporary, local as well as global, and of significance both in everyday life and periods of cultural crisis. In this lecture, Aftab Omer will consider how to develop core principles and practices that are responsive to the challenges of otherness both within the city and beyond. The diversity we see in the human race is often treated as a problem rather than an asset. For example, we see this in various forms of social oppression such as inequality, racism and cultural trauma. Omer argues that responding effectively to the fragmentation that characterises this global cultural crisis, calls for leadership that practices a profound engagement with all that is other. Such a perspective will raise important insights and questions about how people, organisations and cultures relate to each other, with important consequences for the pursuit of wellbeing.